It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. It has a role as a bacterial xenobiotic metabolite. For additional information on the health effects of this chemical, interested parties are referred to the. Optic nerve inflammation, demyelination, and axonal loss are prominent features of optic neuritis, an inflammatory optic neuropathy often associated with the. First aid measures general advice consult a physician. Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2,4dinitrophenol. Dnp is used in developing photography, killing fungi, and as an industrial pesticide. Dinitrophenol definition of dinitrophenol by medical.
Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Incompatible with heavy metals and their compounds. Safety data sheet northwest missouri state university. Dnp 2,4dinitrophenol dnp was first introduced to the bodybuilding world by dan duchaine. We present a case of a healthy 25yearold girl who took two tablets of dnp, purchased from an overseas online retailer. Sep 26, 2019 the atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Tandem mass spectrometry data independently generated by scripps center for metabolomics is available to view or download in pdf. It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. Files are available under licenses specified on their description page. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system.
We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2, 4 dinitrophenol 2, 4 dnp. This material does not contain any class 2 ozone depletors. Structure, properties, spectra, suppliers and links for. We have the list of top 2,4dinitrophenol suppliers, manufacturers, wholesalers and traders with the best price listed from worldwide. This page is regularly updated, to include the most recently available clinical trial evidence. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Also incompatible with strong oxidizing agents, strong bases and reducing agents. It is extremely toxic in overdose and has a narrow therapeutic window with significant interindividual variability in metabolism. Wear goggles, selfcontained breathing apparatus, and rubber overclothing. Dnp is also abused as a fat loss aid by dieters and bodybuilders. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. This is most of the info i used when i was researching dnp and some new stuff. Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own.
A phenolate anion obtained from 2, 4 dinitrophenol. Analytical, diagnostic and therapeutic context of 2,4. Sep 17, 2015 buy dnp 2, 4 dinitrophenol not for human consumption. Classified as an uncoupler of oxidative phosphorylation medically, it is quite. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2,4dinitrophenol 2,4dnp. Media in category 2,4dinitrophenol the following 9 files are in this category, out of 9 total. It is a yellow, crystalline solid that has a sweet, musty odor. The mechanism of uncoupling of oxidative phosphorylation. At first, add water into the pot, stir and heat it to 60 c, then add the melting 2,4dinitrochlorobenzene and continue to heat up to 90 c. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Naruto the setting dawn mod for little fighter 2 mod db. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes. This has been the case with 2, 4 dinitrophenol dnp, which despite abundant evidence of its.
The rise in internetbased sales and distribution of this drug has seen an increased incidence of both accidental and intentional overdose presenting to emergency departments. There is no compound on earth that can burn fat at the rate of dnp. She was managed with aggressive, invasive cooling measures and 2. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. This page was last edited on 12 february 2016, at 20. How to sew a reusable face mask with filter pocket diy fabric face mask batch sew medical mask duration. Aldifen alpha dinitrophenol 1hydroxy 2, 4 dinitrobenzene keep people away. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested.
It is a yellow, crystalline solid that has a sweet, musty. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. Editorthere are only a few cases in the literature of 2,4dinitrophenol dnp poisoning in adults resulting in death. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. There has been a resurgence in the use of 2,4dinitrophenol, c6h4n2o5 recently as an illegal weight loss drug. Like tnt, it was found to be toxic to the munition workers handling it. A substance used locally on humans and other animals to destroy harmful microorganisms or to inhibit their activity cf. Other pertinent literature is also presented, but is described in less detail than the key studies. The model predicted thiobencarb concentrations from rice fields for multiple years throughout. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. It is used in dyes, photo developers, explosives, and as a preservative of lumber.
Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Associations of 2,4dinitrophenol with other chemical compounds. Chemical compound and disease context of 2,4dinitrophenol. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Show this safety data sheet to the doctor in attendance. Ignoring these hard won lessons, and having additional patients repeat the suffering is a most pitiful waste. Boasting an astounding 50% increase in metabolic rate, it is able to contribute to reported fat losses of 1012 pounds in 8 days of use.
Identification 2,4dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. Mitochondrial uncoupler prodrug of 2,4dinitrophenol. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. Jan 10, 2004 there has been a resurgence in the use of 2, 4 dinitrophenol, c6h4n2o5 recently as an illegal weight loss drug. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. Dnp 2,4 dinitrophenol info with all the dnp threads ive seen lately i thought it would be a good idea to post my compilation of dnp info. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2, 4 dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b. Uses the predominant use of 2, 4 dinitrotoluene is as an intermediate in the manufacture of polyurethanes.
Warnings issued over deadly dnp diet drug thursday 19 september 20 tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Pdf environmental fate and impact assessment of thiobencarb. Dnp 2,4dinitrophenol, an industrial chemical with various applications, has gained steady popularity as a fat loss tool. Looking for online definition of dinitrophenol or what dinitrophenol stands for. This material does not contain any class 1 ozone depletors. The lowest published lethal human oral dose of dnp is 4. Reason for citation 2, 4 dinitrophenol is on the hazardous substance list because it is cited by epa. Sports medicinebodybuilding a potent nonselective inhibitor of oxidative phosphorylation, which results in increased metabolism and increased body temperature, and has been used illegally for weight control toxicology any of a family of compounds used in weed control and, at one time, for weight control, which may cause death. Identification 2, 4 dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. An industrial chemical, 2,4dinitrophenol dnp, has found use as a weight loss drug. Parchem is open and ready to supply materials 18002823982 read more. If you subscribed, you got a bunch of audio cassettes containing interviews with 10 bodybuilding experts.
Using 2,4dnp as a shell filling was less sensitive than picric acid on its own. The ability of novel mitochondrial uncoupler prodrug of 2,4dinitrophenol dnp, mp201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis eae model of optic neuritis was evaluated. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. Medical knowledge, especially in toxicology, is built on experimentation and the preciously won experience over time treating the ingestions and poisonings of our patients. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. The prevalence of nonprescription weight loss measures is increasing. It is primarily used as an antiseptic, but has a number of uses in industry, in the manufacture of explosives and herbicides, and it is considered to be an industrial pollutant. Reason for citation 2,4dinitrophenol is on the hazardous substance list because it is cited by epa. Im including everything i have whether i agree with it or not, because there is no one right way to run dnp. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. All structured data from the file and property namespaces is available under the creative commons cc0 license.
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